Having begun as a small town, North Carolina schoolgirl in Blue Velvet, and then raised hell racing across the country in Wild at Heart, it’s perhaps only logical that Lynch and Dern would end up in Hollywood for their third and, as of this moment, final collaboration. It’s a typically unsettling Lynchian take on the American road movie, but Dern and Cage sell the runaways as a genuine love match whose healthy sex life helps to make this the director’s most tender movie. The film, a classic 'lovers on the run' story, sees Lula and her ex-con boyfriend Sailor (Cage) smoke, screw, fight and head-bang their way across America in a bid to escape Lula’s wicked mother. Dressed in skintight blacks and hot pinks, with aviator sunglasses and a perpetual cigarette, Lula was quite a departure from the pastel-clad Sandy. It was in her next role for Lynch, in his adaptation of Barry Gifford's novel Wild at Heart, that Dern was to really impress, proving herself every bit Nicholas Cage’s equal as the highly-sexed, rock-chick-tearaway Lula. Laura Dern and Kyle MacLachlan in Blue Velvet

Dern dropped out of college to appear in Blue Velvet and she acquits herself admirably as the sane centre of the film - however she was always destined to take a backseat to larger-than-life turns by Dennis Hopper and Isabella Rosselini. Dern plays inexperienced high schooler Sandy, a police detective's daughter who is dragged into a world of local gangsters, voyeurism and sado-masochism by the potent combination of dishy older neighbour Jeffrey (Kyle MacLachlan) and her own curiosity.

The pair began their collaboration in 1986 with the neo-noir Blue Velvet, a film that takes us under the hood of small town Americana in order to expose the rot festering below. But it is Laura Dern, star of Blue Velvet, Wild at Heart and Inland Empire, who has done the most to help Lynch in his career-long effort to probe, warp and disturb the dreams of America. Sheryl Lee ( Twin Peaks, Twin Peaks: Fire Walk With Me), Patricia Arquette ( Lost Highway) and Naomi Watts ( Mulholland Drive) have all had their turns.

Like Alfred Hitchcock before him, David Lynch has shown more than a passing interest in placing the American Blonde on screen. Inspired by Glasgow Film Festival's upcoming screening of David Lynch's Wild at Heart at St Luke's – complete with an Elvis tribute – we look back at the director's trio of collaborations with the beating heart of that film, Laura Dern.

Wild at heart movie trailer